"There is great excitement about the potential of senolytic drugs to treat all kinds of diseases of…
"There is great excitement about the potential of senolytic drugs to treat all kinds of diseases of aging,"
AbbVie’s cancer drug Venclexta blocks diabetes in mice by targeting beta cell ‘senescence’ | FierceBiotech
A UCSF team found that beta cells experience "secretory senescence," a process whereby DNA damage causes them to stop working properly. That touches off the immune attack on beta cells that's characteristic of Type 1 diabetes. In mice, a drug that eradicates senescent cells—AbbVie’s leukemia treatment Venclexta—prevented the onset of the disease.